Nasyrov Kh M, Lazareva D N
Farmakol Toksikol. 1984 Jan-Feb;47(1):84-8.
The action on the reparative stage of inflammation of acetylsalicylic, ascorbic and mephenamic acids, amidopyrine, analgin, butadion, ibuprophen, indomethacin, voltaren, glycyrrhizic acid and its penta-O-nicotinate, delagil, methyluracil, and prednisolone was evaluated from the rate of the healing of skin wounds in mice and rats, formation of the granulation tissue on the integmentary glass implanted into the subcutaneous fat from the effect on the functional status of fibroblast chromatin and changes in phagocytosis. Prednisolone, indomethacin voltaren, delagil, appeared to inhibit whereas amidopyrine, acetylsalicylic acid, butadion, ibuprophen and methyluracil to stimulate the reparative stage of inflammation. The anti-inflammatory agents that stimulated reparative regeneration raised the functional activity of chromatin.
通过观察小鼠和大鼠皮肤伤口的愈合速度、植入皮下脂肪的皮肤玻璃上肉芽组织的形成情况、对成纤维细胞染色质功能状态的影响以及吞噬作用的变化，评估了乙酰水杨酸、抗坏血酸、甲灭酸、氨基比林、安乃近、布他酮、布洛芬、吲哚美辛、扶他林、甘草酸及其五 - O - 烟酸盐、地拉吉、甲基尿嘧啶和泼尼松龙在炎症修复阶段的作用。泼尼松龙、吲哚美辛、扶他林、地拉吉似乎具有抑制作用，而氨基比林、乙酰水杨酸、布他酮、布洛芬和甲基尿嘧啶则能刺激炎症的修复阶段。刺激修复性再生的抗炎药物提高了染色质的功能活性。
