Khovanskikh A E, Krylov M V, Zaĭonts V I, Korovitskaia L A, Sokolov A N
Farmakol Toksikol. 1984 Jan-Feb;47(1):95-8.
The data on the pharmacokinetics are provided and toxicological characteristics is described in detail of a new highly effective anticoccidal and antitoxoplasmic drug chimcoccide (1,3-bis-/p-chlorbenzylidenamino/guanidine). Chimcoccide is not toxic when applied in prophylactic and therapeutic doses (6 and 12 mg/kg) for coccidosis and toxoplasmosis of animals. It does not disturb the biosynthesis of DNA, RNA, protein or activity of NADP-specific malate dehydrogenase and isocitrate dehydrogenase in organs and tissues of animals. When given in the doses indicated the drug inhibits mitochondrial monoamine oxidase of the brain and liver of rats and chickens.
提供了关于一种新型高效抗球虫和抗弓形虫药物奇莫克西德（1,3-双-/对氯苄叉氨基/胍）的药代动力学数据，并详细描述了其毒理学特性。当以预防和治疗剂量（6和12毫克/千克）用于动物的球虫病和弓形虫病时，奇莫克西德无毒。它不会干扰动物器官和组织中DNA、RNA、蛋白质的生物合成或NADP特异性苹果酸脱氢酶和异柠檬酸脱氢酶的活性。当给予所示剂量时，该药物会抑制大鼠和鸡大脑和肝脏中的线粒体单胺氧化酶。
