Nikitina G V
Farmakol Toksikol. 1991 Mar-Apr;54(2):43-6.
In the experiments on mature females of 50 rats, 10 rabbits, 8 dogs it was established that a new gestagenic drug acetomepregenol was not toxic both for pregnant and nonpregnant animals. The two-month administration of the drug in the therapeutic and maximal doses did not exert the irreversible effects on the reproductive function and did not influence the embryonal and postnatal development of the offspring. A single administration of acetomepregenol in the critical periods of pregnancy was found to exert the embryotoxic effect which did not manifest itself during daily administration of the drug from the 6th through the 16th days of pregnancy.
在对50只大鼠、10只兔子、8只狗的成年雌性动物进行的实验中发现，一种新的孕激素药物醋美孕酮对怀孕和未怀孕的动物均无毒。以治疗剂量和最大剂量连续两个月给药该药物，对生殖功能没有产生不可逆影响，也未影响后代的胚胎发育和出生后的发育。发现在怀孕的关键时期单次给予醋美孕酮会产生胚胎毒性作用，但在怀孕第6天至第16天每日给药该药物时并未表现出这种作用。
