Prescott L F
Biochem Soc Trans. 1984 Feb;12(1):96-9. doi: 10.1042/bst0120096.
Conjugation is an important mechanism for the rapid inactivation and extensive removal of drugs and poisons from the body, and as such it is of major significance in clinical toxicology. The capacity for conjugation of some drugs is large, but with others, saturation may occur with overdosage or even high therapeutic doses. Glutathione conjugation is an important mechanism of protection against toxicity produced by heavy metals, alkylating agents and some compounds which undergo metabolic activation.
结合作用是药物和毒物从体内快速失活并大量清除的重要机制，因此在临床毒理学中具有重要意义。某些药物的结合能力很强，但其他一些药物在过量用药甚至高治疗剂量时可能会发生饱和现象。谷胱甘肽结合作用是抵御重金属、烷化剂及某些经代谢活化的化合物所产生毒性的重要保护机制。
