Kubo Y, Okuda K, Shimokawa Y, Arishima T, Nagata E
Gastroenterology. 1977 Jun;72(6):1213-6.
Hepatitis B surface antigen was determined in sera of 122 cases of hepatocellular carcinoma seen in Japan, using both the counterimmunoelectrophoresis and radioimmunoassay (RIA) techniques. It was positive in 49.2% of the patients with RIA, but the level of antigen in serum was relatively low since positivity rate by counterimmunoelectrophoresis was only 10.7%, The degree of antigenemia as assessed from the count relative to the cut-off value in RIA, was increased during the clinical course in 75% of the patients. The antigen tended to rise in concentration when the tumor grew at a rapid rate, when damage to liver parenchyma was extensive, or in patients receiving chemotherapy. There was also a tendency for less frequent positive antigen tests in patients with higher alpha-fetoprotein levels. Illustrative cases are presented with discussion on the possible explanation for the change in the degree of antigenemia.
采用对流免疫电泳和放射免疫测定（RIA）技术，对日本122例肝细胞癌患者的血清进行了乙肝表面抗原检测。RIA检测显示49.2%的患者呈阳性，但血清中的抗原水平相对较低，因为对流免疫电泳的阳性率仅为10.7%。根据RIA中相对于临界值的计数评估，75%的患者在临床过程中抗原血症程度增加。当肿瘤快速生长、肝实质损伤广泛或患者接受化疗时，抗原浓度往往会升高。甲胎蛋白水平较高的患者抗原检测呈阳性的频率也有较低的趋势。文中给出了示例病例，并讨论了抗原血症程度变化的可能原因。
