Davidowitz J, Philips G, Chiarandini D J, Breinin G M
Graefes Arch Clin Exp Ophthalmol. 1984;221(4):153-6. doi: 10.1007/BF02134256.
An abnormal superior rectus muscle of rat displayed marked differences in the respective distributions of mitochondrial alterations and excessive lipid accumulations, both of which are thought to be indicators of faulty oxidative metabolism. The mitochondrial alterations were widespread, extending over 46% of muscle length. In contrast, the excess lipids extended over but 11% of the muscle length and were virtually confined to the end-plate region. The end plates themselves were essentially normal. These data raise the possibility that the end-plate region may exhibit a locally greater deficit of oxidative metabolism, due to a possibly higher metabolic requirement needed to support the localized end-plate potential activity.
大鼠异常上直肌在线粒体改变和脂质过度积累的各自分布上表现出明显差异，这两者都被认为是氧化代谢异常的指标。线粒体改变广泛存在，延伸至肌肉长度的46%。相比之下，过量脂质仅延伸至肌肉长度的11%，且几乎局限于终板区域。终板本身基本正常。这些数据增加了一种可能性，即由于支持局部终板电位活动可能需要更高的代谢需求，终板区域可能表现出局部更大的氧化代谢缺陷。
