Zach M
Fortschr Med. 1984 Mar 8;102(9):235-7.
Three consecutive studies were concerned with clinical, pathophysiologic, and immunologic aspects of recurrent croup. The first investigation demonstrated that recurrent croup is a distinct disease entity which shares many clinical features with asthma and should be distinguished from viral laryngotracheobronchitis. In the second study a high incidence of airway hyperreactivity was found in children with recurrent croup. This specific type of hyperreactivity suggested an involvement of both the lower and the upper respiratory tract. The third study demonstrated a tendency towards low serum IgA levels in children with recurrent croup; hence immunoregulatory defects may be conducive to the development of this disorder.
三项连续的研究涉及复发性哮吼的临床、病理生理和免疫学方面。第一项研究表明，复发性哮吼是一种独特的疾病实体，与哮喘有许多共同的临床特征，应与病毒性喉气管支气管炎相区分。在第二项研究中，发现复发性哮吼患儿气道高反应性的发生率很高。这种特定类型的高反应性提示上下呼吸道均受累。第三项研究表明，复发性哮吼患儿有血清IgA水平降低的倾向；因此，免疫调节缺陷可能有助于这种疾病的发展。
