Zach M S
Eur J Respir Dis Suppl. 1983;128 (Pt 1):81-8.
Three subsequent studies were concerned with clinical, pathophysiologic and immunologic aspects of recurrent croup. The first investigation demonstrated that recurrent croup is a distinct disease entity which shares many clinical features with asthma and should be distinguished from viral laryngotracheobronchitis. A high incidence of airway hyperreactivity was found in children with recurrent croup in the second study. This specific type of hyperreactivity suggested an involvement of both the lower and the upper respiratory tract. The third study demonstrated a tendency towards low serum IgA levels in children with recurrent croup; hence immunoregulatory defects may be conducive to the development of this disorder.
随后的三项研究关注复发性哮吼的临床、病理生理和免疫学方面。第一项调查表明，复发性哮吼是一种独特的疾病实体，与哮喘有许多共同的临床特征，应与病毒性喉气管支气管炎相区别。第二项研究发现复发性哮吼患儿气道高反应性的发生率很高。这种特定类型的高反应性表明上下呼吸道均受累。第三项研究表明，复发性哮吼患儿有血清IgA水平偏低的倾向；因此，免疫调节缺陷可能有助于这种疾病的发展。
