Brückle W, Lydtin H
Fortschr Med. 1984 Mar 8;102(9):241-3.
In an open study in patients with tumour-induced pain the analgetic effects of the prostaglandin-inhibiting compound diflunisal and the centrally-acting analgetic tilidine N were compared. A dosage of 1 g diflunisal was found to be equivalent to 50 drops of tilidine N and to be subjectively well-tolerated. In the pain-relieving therapy of tumour patients diflunisal appears to offer a genuine alternative to centrally-acting analgetics.
在一项针对肿瘤引起疼痛患者的开放性研究中,比较了前列腺素抑制化合物二氟尼柳和中枢性镇痛药替利定N的镇痛效果。发现1克二氟尼柳的剂量相当于50滴替利定N,且患者主观耐受性良好。在肿瘤患者的止痛治疗中,二氟尼柳似乎是中枢性镇痛药的一种真正替代药物。