Morse D R, Furst M L, Koren L Z, Bolanos O R, Esposito J V, Yesilsoy C
Department of Endodontology, Temple University School of Dentistry, Philadelphia, Pennsylvania.
Clin Ther. 1987;9(5):500-11.
One hundred seventy-nine patients with asymptomatic or mildly symptomatic endodontic disease had single-visit therapy and were given either diflunisal (n = 94) or aspirin with codeine (n = 85) to control posttreatment pain. In this open-label, randomized study, diflunisal was judged superior to the aspirin-codeine combination in all major categories evaluated. Of patients receiving diflunisal, 93.6% needed the medication for only one day. In contrast, 77.7% of patients receiving aspirin with codeine needed the medication for only one day. Almost 64% of patients receiving diflunisal needed only one dose, while 32.9% of patients using aspirin with codeine needed only one dose. Four or more doses were required by 5.3% of patients receiving diflunisal and by 23.5% of patients receiving the aspirin-codeine combination. In patients receiving diflunisal, 20.2% experienced side effects. In contrast, 29.4% of patients receiving aspirin with codeine reported side effects. Thirty-five percent of patients receiving diflunisal rated the analgesic as excellent; 5.3% rated it as fair or poor. In contrast, 12.9% of patients receiving aspirin with codeine rated the analgesic combination as excellent; another 12.9% rated it as fair or poor. Diflunisal was found to be generally effective and well-tolerated, and superior to aspirin with codeine in the management of pain from endodontic treatment.
179例无症状或症状轻微的牙髓病患者接受了一次性治疗，并给予双氯芬酸（n = 94）或阿司匹林可待因（n = 85）以控制治疗后疼痛。在这项开放标签的随机研究中，在所有评估的主要类别中，双氯芬酸被判定优于阿司匹林 - 可待因组合。接受双氯芬酸的患者中，93.6%仅需用药一天。相比之下，接受阿司匹林可待因的患者中有77.7%仅需用药一天。接受双氯芬酸的患者中近64%仅需一剂，而使用阿司匹林可待因的患者中有32.9%仅需一剂。接受双氯芬酸的患者中有5.3%需要四剂或更多剂量，接受阿司匹林 - 可待因组合的患者中有23.5%需要四剂或更多剂量。接受双氯芬酸的患者中有20.2%出现副作用。相比之下，接受阿司匹林可待因的患者中有29.4%报告有副作用。接受双氯芬酸的患者中有35%将止痛药评为优秀；5.3%评为一般或差。相比之下，接受阿司匹林可待因的患者中有12.9%将止痛组合评为优秀；另有12.9%评为一般或差。发现双氯芬酸总体有效且耐受性良好，在治疗牙髓病疼痛方面优于阿司匹林可待因。
