Uracz W, Bobrzecka K, Konieczny L, Rybarska J, Zembala M
Immunol Lett. 1984;7(4):215-20. doi: 10.1016/0165-2478(84)90046-4.
Immunoglobulin species, recombined from Fab and Fc fragments with anti-red cell specificity were used as cytophilic antibodies in studies of triggering the effector activity of immunoglobulins. Recombinant immunoglobulins containing a single Fab' appeared inactive in binding to cell receptors and triggering antibody dependent cellular cytotoxicity, while those with two Fab' exhibited an activity comparable to intact antibody IgG. The experiments indicate that Fab fragment may interact with Fc and inhibit its binding to cell receptors.
从具有抗红细胞特异性的Fab和Fc片段重组而来的免疫球蛋白种类，被用作嗜细胞抗体，用于触发免疫球蛋白效应活性的研究。含有单个Fab'的重组免疫球蛋白在与细胞受体结合及触发抗体依赖性细胞毒性方面表现出无活性，而含有两个Fab'的重组免疫球蛋白则表现出与完整抗体IgG相当的活性。实验表明，Fab片段可能与Fc相互作用并抑制其与细胞受体的结合。
