Bahna S L, Heiner D C, Horwitz C A
Int Arch Allergy Appl Immunol. 1984;74(1):1-8. doi: 10.1159/000233507.
Serum total IgG, IgA, IgM, IgD, and IgE concentrations, heterophil antibody titer, Epstein-Barr virus (EBV)-specific antibodies titer, and hematologic changes were studied longitudinally in 19 patients with EBV-induced infectious mononucleosis who were followed up for 1.5-34 months. In 9 patients, the changes in these variables were compared with baseline data on a pre-illness serum sample. All 5 immunoglobulins (Ig) showed a significant rise during the acute illness followed by a drop during convalescence, and a gradual 'normalization' within several months to a year. On the average, IgE peaked to 276% during the first week, IgM to 176% at about 10 days, IgA to 154% at 15-20 days, IgG to 135% at 10-15 days, and IgD to 141% during the first 2 months after onset. IgE and IgM levels were significantly suppressed during convalescence by an average of about 40 and 25% of pre-illness level, respectively. A relationship was noted between Ig rise and the increase in circulating atypical lymphocytes. The data clearly demonstrate the polyclonal nature of Ig production during the acute phase of EBV-induced mononucleosis, with a striking and early reactivity of IgE.
对19例由EB病毒引起的传染性单核细胞增多症患者进行了1.5至34个月的纵向研究,观察血清总IgG、IgA、IgM、IgD和IgE浓度、嗜异性抗体滴度、EB病毒(EBV)特异性抗体滴度及血液学变化。其中9例患者,将这些变量的变化与病前血清样本的基线数据进行了比较。所有5种免疫球蛋白(Ig)在急性期均显著升高,随后在恢复期下降,并在数月至一年内逐渐“恢复正常”。平均而言,IgE在第一周达到峰值,为276%;IgM在约10天时达到176%;IgA在15至20天时达到154%;IgG在10至15天时达到135%;IgD在发病后前两个月达到141%。恢复期IgE和IgM水平分别平均比病前水平显著降低约40%和25%。观察到Ig升高与循环中异型淋巴细胞增加之间存在关联。数据清楚地表明,EB病毒引起的单核细胞增多症急性期Ig产生具有多克隆性质,IgE具有显著且早期的反应性。