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传染性单核细胞增多症中五种免疫球蛋白类别的顺序变化及其他反应。

Sequential changes of the five immunoglobulin classes and other responses in infectious mononucleosis.

作者信息

Bahna S L, Heiner D C, Horwitz C A

出版信息

Int Arch Allergy Appl Immunol. 1984;74(1):1-8. doi: 10.1159/000233507.

DOI:10.1159/000233507
PMID:6706423
Abstract

Serum total IgG, IgA, IgM, IgD, and IgE concentrations, heterophil antibody titer, Epstein-Barr virus (EBV)-specific antibodies titer, and hematologic changes were studied longitudinally in 19 patients with EBV-induced infectious mononucleosis who were followed up for 1.5-34 months. In 9 patients, the changes in these variables were compared with baseline data on a pre-illness serum sample. All 5 immunoglobulins (Ig) showed a significant rise during the acute illness followed by a drop during convalescence, and a gradual 'normalization' within several months to a year. On the average, IgE peaked to 276% during the first week, IgM to 176% at about 10 days, IgA to 154% at 15-20 days, IgG to 135% at 10-15 days, and IgD to 141% during the first 2 months after onset. IgE and IgM levels were significantly suppressed during convalescence by an average of about 40 and 25% of pre-illness level, respectively. A relationship was noted between Ig rise and the increase in circulating atypical lymphocytes. The data clearly demonstrate the polyclonal nature of Ig production during the acute phase of EBV-induced mononucleosis, with a striking and early reactivity of IgE.

摘要

对19例由EB病毒引起的传染性单核细胞增多症患者进行了1.5至34个月的纵向研究,观察血清总IgG、IgA、IgM、IgD和IgE浓度、嗜异性抗体滴度、EB病毒(EBV)特异性抗体滴度及血液学变化。其中9例患者,将这些变量的变化与病前血清样本的基线数据进行了比较。所有5种免疫球蛋白(Ig)在急性期均显著升高,随后在恢复期下降,并在数月至一年内逐渐“恢复正常”。平均而言,IgE在第一周达到峰值,为276%;IgM在约10天时达到176%;IgA在15至20天时达到154%;IgG在10至15天时达到135%;IgD在发病后前两个月达到141%。恢复期IgE和IgM水平分别平均比病前水平显著降低约40%和25%。观察到Ig升高与循环中异型淋巴细胞增加之间存在关联。数据清楚地表明,EB病毒引起的单核细胞增多症急性期Ig产生具有多克隆性质,IgE具有显著且早期的反应性。

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Sequential changes of the five immunoglobulin classes and other responses in infectious mononucleosis.传染性单核细胞增多症中五种免疫球蛋白类别的顺序变化及其他反应。
Int Arch Allergy Appl Immunol. 1984;74(1):1-8. doi: 10.1159/000233507.
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