Sezai Y, Umeda S, Okazaki T, Okamoto I, Rikukawa H, Shiono M
J Cardiovasc Surg (Torino). 1984 Jan-Feb;25(1):16-24.
We performed valvular replacement in 86 cases (108 valves, 43 males, 43 females) from July 1978 to July 1981 with St. Jude Medical valves which utilize two discs made of pyrolytic carbon and employ a bileaflet central opening system. Ages ranged from 13 to 68 years (average 42.3). For all cases in this study, we performed anti-coagulant therapy. The incidence of thromboembolic complication was zero. With regard to postoperative clinical evaluation on valve function and chronic hemolysis, we compared the cases of St. Jude Medical valves with those of Starr-Edwards (S.E.) valves (aortic: Model 2320, mitral: Model 6400), Carpentier-Edwards (C.E.) valves and cases of open mitral commissurotomy. As for valve function such as left atrioventricular diastolic pressure gradient, mitral effective orifice area both at rest and on exercise, the St. Jude Medical valve yielded best results. Next was the C.E. and third was the S.E. The results of the St. Jude Medical valve group and those of the open mitral commissurotomy group were equivalent. In comparison with ball type cardiac valve prostheses and bioprostheses, the St. Jude Medical valve has excellent hemodynamic characteristic. Concerning hemolysis, the St. Jude Medical was below only the C.E., however the degree of hemolysis was so low that the St. Jude Medical valve holds great promise as central flow mechanical valve prostheses.
1978年7月至1981年7月期间，我们使用圣犹达医疗公司生产的瓣膜为86例患者（共108个瓣膜，男43例，女43例）进行了瓣膜置换手术。该瓣膜采用两片热解碳制成的圆盘，并采用双叶中心开口系统。患者年龄在13至68岁之间（平均42.3岁）。对于本研究中的所有病例，我们都进行了抗凝治疗。血栓栓塞并发症的发生率为零。关于瓣膜功能和慢性溶血的术后临床评估，我们将圣犹达医疗瓣膜的病例与斯塔尔-爱德华兹（S.E.）瓣膜（主动脉瓣：型号2320，二尖瓣：型号6400）、卡彭蒂埃-爱德华兹（C.E.）瓣膜的病例以及二尖瓣直视分离术的病例进行了比较。至于瓣膜功能，如左房室舒张期压力梯度、静息和运动时二尖瓣有效瓣口面积，圣犹达医疗瓣膜的效果最佳。其次是C.E.瓣膜，第三是S.E.瓣膜。圣犹达医疗瓣膜组和二尖瓣直视分离术组的结果相当。与球型心脏瓣膜假体和生物假体相比，圣犹达医疗瓣膜具有出色的血流动力学特性。关于溶血，圣犹达医疗瓣膜仅低于C.E.瓣膜，然而溶血程度非常低，以至于圣犹达医疗瓣膜作为中心血流机械瓣膜假体具有很大的前景。
