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[多普勒超声心动图在评估机械和生物心脏瓣膜假体中的应用]

[Doppler echocardiography in assessing mechanical and biological heart valve prostheses].

作者信息

Minardi G, Di Segni M, Boccardi L, Ferrari O, Giovannini E

机构信息

Servizio di Poligrafia, Ospedale S. Camillo, Roma.

出版信息

G Ital Cardiol. 1988 Feb;18(2):121-34.

PMID:3410201
Abstract

The study was performed to assess Doppler echocardiographic features of mitral and aortic prosthetic valves of different types with both normal and abnormal function. Two hundred and twenty-three patients with 250 prostheses were studied. Two hundred eight valves (111 mitral, 95 aortic and 2 tricuspid) were considered to be functioning normally after clinical examination, phonocardiography and M-mode and 2D echocardiography. This group enabled us to define normal Doppler echocardiographic findings for different types of prosthesis. In mitral position, peak (p) and mean (m) gradients were lower for disc prostheses and higher for ball and biological prosthetic valves; values of effective orifice area (A), calculated by pressure half-time method, were lower for biological and ball prostheses and higher in disc valves. Results were as follows: St. Jude (p 10.6 mmHg, m 3.9 mmHg, A 2.7 cm2), Duromedics (p 10.6, m 4.3, A 2.8), Björk-Shiley (p 10.4, m 4, A 2.3), Omniscience (p 14.2, m 6.2, A 2.1), Starr-Edwards (p 15.9, m 5.4, A 2.1), Hancock (p 14.7, m 6, A 2), Carpentier (p 13.2, m 5.4, A 1.9). Mild regurgitation, considered "physiological", was found in 2/8 Carpentier valves and in 3/34 St. Jude prostheses. In aortic valves lower peak gradients were found in Lillehei (18.3 mmHg), St. Jude (23.8 mmHg), Björk-Shiley (26 mmHg), Duromedics (27 mmHg) and higher values in Starr-Edwards (30.2 mmHg), Hancock (30 mmHg) and Omniscience (35.5 mmHg) prostheses. Mild regurgitation, considered "physiological", was found in 17% of Omniscience valves, 21% of Hancock, 33% of Duromedics, 45% of St. Jude, 60% of Björk-Shiley prostheses. Hancock mitral valves implanted for over 7 years had a mean gradient higher than valves with a shorter period of implantation (7.6 vs 4.85 mmHg, p less than 0.1), whereas the effective orifice area was similar. Hancock aortic valves implanted for over 7 years had a peak gradient slightly higher than the other group (implantation less than 7 years previously), but the difference was not statistically significant. Forty-two valves (19 aortic and 23 mitral) were considered to be malfunctioning. Regurgitation Doppler signals of malfunctioning valves appeared different from those of "physiological" reverse flow; in the former cases forward gradient was higher than normal prostheses. In stenotic aortic prostheses, peak systolic gradient was greatly increased; in stenotic mitral prostheses, a very significant increase in mean gradient and a great decrease in effective orifice area were found. In 14 patients who underwent surgical re-operation and in the patient who died before operation, Doppler echocardiographic findings were confirmed.(ABSTRACT TRUNCATED AT 400 WORDS)

摘要

本研究旨在评估不同类型、功能正常及异常的二尖瓣和主动脉人工瓣膜的多普勒超声心动图特征。对223例患者的250个假体进行了研究。经临床检查、心音图、M型和二维超声心动图检查,208个瓣膜(111个二尖瓣、95个主动脉瓣和2个三尖瓣)被认为功能正常。该组使我们能够确定不同类型假体的正常多普勒超声心动图表现。在二尖瓣位置,碟形假体的峰值(p)和平均(m)梯度较低,球型和生物假体瓣膜的较高;通过压力半衰期法计算的有效瓣口面积(A)值,生物和球型假体较低,碟形瓣膜较高。结果如下:圣犹达(p 10.6 mmHg,m 3.9 mmHg,A 2.7 cm²)、杜洛美迪克(p 10.6,m 4.3,A 2.8)、比约克-希利(p 10.4,m 4,A 2.3)、全知(p 14.2,m 6.2,A 2.1)、斯塔尔-爱德华兹(p 15.9,m 5.4,A 2.1)、汉考克(p 14.7,m 6,A 2)、卡朋蒂埃(p 13.2,m 5.4,A 1.9)。在2/8个卡朋蒂埃瓣膜和3/34个圣犹达假体中发现轻度反流,被认为是“生理性”的。在主动脉瓣中,利勒黑(18.3 mmHg)、圣犹达(23.8 mmHg)、比约克-希利(26 mmHg)、杜洛美迪克(27 mmHg)的峰值梯度较低,斯塔尔-爱德华兹(30.2 mmHg)、汉考克(30 mmHg)和全知(35.5 mmHg)假体的峰值梯度较高。在17%的全知瓣膜、21%的汉考克瓣膜、33%的杜洛美迪克瓣膜、45%的圣犹达瓣膜、60%的比约克-希利假体中发现轻度反流,被认为是“生理性”的。植入超过7年的汉考克二尖瓣平均梯度高于植入时间较短的瓣膜(7.6对4.85 mmHg,p小于0.1),而有效瓣口面积相似。植入超过7年的汉考克主动脉瓣峰值梯度略高于另一组(植入时间少于7年),但差异无统计学意义。42个瓣膜(19个主动脉瓣和23个二尖瓣)被认为功能异常。功能异常瓣膜的反流多普勒信号与“生理性”反流不同;在前一种情况下,正向梯度高于正常假体。在狭窄的主动脉人工瓣膜中,收缩期峰值梯度大幅增加;在狭窄的二尖瓣人工瓣膜中,平均梯度显著增加,有效瓣口面积大幅减小。在14例接受手术再次操作的患者和术前死亡的患者中,多普勒超声心动图结果得到证实。(摘要截于400字)

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