由神经抗原和流感疫苗混合物诱导的实验性神经炎。格林-巴利综合征的一种可能模型。

Experimental neuritis induced by a mixture of neural antigens and influenza vaccines. A possible model for Guillain-Barré syndrome.

作者信息

Hjorth R N, Bonde G M, Piner E, Hartzell R W, Rorke L B, Rubin B A

出版信息

J Neuroimmunol. 1984 Feb;6(1):1-8. doi: 10.1016/0165-5728(84)90037-7.

Abstract

We describe the development in rats of a possible model for Guillain-Barré syndrome (GBS): experimental neuritis (EN). The clinical symptoms, histopathology and the presence of antibody to nervous tissue are features that EN has in common with both GBS and experimental allergic neuritis (EAN), another GBS model. However, EN may be a more appropriate model than EAN for studying the role of autoimmune reactions in diseases such as GBS, which are triggered by various viruses or antigens, since EN depends on such agents being administered concomitantly with the syngeneic tissue.

摘要

我们描述了大鼠中一种可能的吉兰 - 巴雷综合征（GBS）模型：实验性神经炎（EN）的发展情况。临床症状、组织病理学以及针对神经组织抗体的存在是EN与GBS以及另一种GBS模型——实验性过敏性神经炎（EAN）共有的特征。然而，EN可能比EAN更适合用于研究自身免疫反应在诸如GBS这类由各种病毒或抗原引发的疾病中的作用，因为EN依赖于此类病原体与同基因组织同时给药。