Ghezzi A, Zaffaroni M, Caputo D, Montanini R, Cazzullo C L
J Neurol Neurosurg Psychiatry. 1986 Aug;49(8):913-9. doi: 10.1136/jnnp.49.8.913.
Evoked potentials and T-lymphocyte helper/suppressor ratio (H/S) were evaluated serially together with neurological status in 30 definite multiple sclerosis patients to evaluate their possible role in monitoring disease progression. Evoked potentials in many cases reflected the clinical status of the pathways tested, but some exceptions were observed, probably due to subclinical relapses or physical factors. In some instances the occurrence of subclinical relapses was suggested by increased H/S ratios. Serial H/S values increased in parallel with clinical and subclinical relapses, and seemed to show specific patterns in relation to the type of clinical course (relapsing, stable, chronic progressive). Our results suggest that evoked potentials and H/S ratio serial analysis can contribute to a better assessment of the progress of multiple sclerosis.
对30例确诊的多发性硬化症患者，连续评估其诱发电位、T淋巴细胞辅助/抑制比例（H/S）以及神经学状态，以评估它们在监测疾病进展中可能发挥的作用。在许多情况下，诱发电位反映了所检测通路的临床状态，但也观察到一些例外情况，这可能是由于亚临床复发或身体因素所致。在某些情况下，H/S比例升高提示亚临床复发的发生。H/S值的连续变化与临床和亚临床复发平行增加，并且似乎与临床病程类型（复发型、稳定型、慢性进展型）呈现特定模式。我们的结果表明，诱发电位和H/S比例的连续分析有助于更好地评估多发性硬化症的进展。
