Vaughan D P
J Pharm Sci. 1984 Feb;73(2):273-4. doi: 10.1002/jps.2600730236.
For an N-compartmental system, with irreversible drug loss from the sampled compartment, the equilibrium concentration, C (infinity), obtained with a zero-order drug input is related to the total amount of drug in the system, T, by C (infinity) V = T. The scalar V is the volume of distribution of the corresponding closed system. The moment functions of the open system define V, and hence T is directly calculable. The derivation is general in the sense that the topology of the system is not specified and no functional form for C (t) is required.
对于一个N房室系统，若从采样房室有不可逆的药物损失，零级药物输入时获得的平衡浓度C（无穷大）与系统中药物总量T的关系为C（无穷大）V = T。标量V是相应封闭系统的分布容积。开放系统的矩函数定义了V，因此T可直接计算。该推导具有一般性，因为未指定系统的拓扑结构，也不需要C（t）的函数形式。
