Shorr R M, Ershler W B, Gamelli R L
J Trauma. 1984 Apr;24(4):319-22. doi: 10.1097/00005373-198404000-00006.
To further characterize immunologic alterations found in thermally injured patients, a series of experiments dealing with lymphocyte immunoglobulin production were performed. Circulating immunoglobulin levels were measured, plasma antitetanus toxoid was quantitated, and lymphocytes were cultured and in vitro immunoglobulin production recorded. Postburn circulating immunoglobulins were initially depressed but returned to normal at a variable rate. We found a normal response to rechallenge with tetanus toxoid. However, culture of lymphocytes in vitro showed that lymphocytes from burned patients had an elevated spontaneous immunoglobulin production and no augmentation with mitogen stimulation. This alteration in immunoglobulin production was not found in a group of postoperative or trauma patients and appears to be unique to burned patients.
为了进一步描述热损伤患者所发现的免疫改变，进行了一系列涉及淋巴细胞免疫球蛋白产生的实验。检测了循环免疫球蛋白水平，定量了血浆抗破伤风类毒素，并培养了淋巴细胞并记录了体外免疫球蛋白的产生。烧伤后循环免疫球蛋白最初降低，但以可变速率恢复正常。我们发现对破伤风类毒素再次激发有正常反应。然而，体外淋巴细胞培养显示，烧伤患者的淋巴细胞自发免疫球蛋白产生升高，且有丝分裂原刺激后无增加。在一组术后或创伤患者中未发现这种免疫球蛋白产生的改变，似乎是烧伤患者所特有的。
