Teodorczyk-Injeyan J A, Sparkes B G, Falk R E, Peters W J
J Trauma. 1986 Sep;26(9):834-9. doi: 10.1097/00005373-198609000-00010.
Spontaneous and pokeweed mitogen (PWM)-induced polyclonal immunoglobulin production in vitro were estimated in patients with severe burns (28-83% TBSA) immediately following their injury and at intervals of 8 to 14 days thereafter. In parallel, functional activity of patients' T lymphocytes was assessed in the mixed lymphocyte reaction (MLR). PWM-induced immunoglobulin secretion, of both IgG and IgM, was elevated in the first 2 to 3 weeks after burn, followed by a period of relatively suppressed antibody response at 3 to 4 weeks. Immunoglobulin production was then apparently restored to baseline or higher levels in surviving patients. However, in patients whose antibody response continued to be suppressed fatal septicemia developed. The background (spontaneous) immunoglobulin synthesis increased significantly over the normal range in 10/78 tests performed. These alterations in mitogen-induced immunoglobulin production were well correlated with changes in the T-cell alloreactivity in the MLR. Thus thermal injury-associated changes in the patients' humoral responses may be a consequence of changes within the T-cell compartment, especially the T-helper cell subset.
对严重烧伤（烧伤总面积28%-83%）患者在受伤后即刻以及此后每隔8至14天，评估其体外自发和商陆丝裂原（PWM）诱导的多克隆免疫球蛋白产生情况。同时，在混合淋巴细胞反应（MLR）中评估患者T淋巴细胞的功能活性。烧伤后最初2至3周，PWM诱导的IgG和IgM免疫球蛋白分泌均升高，随后在3至4周出现一段相对受抑制的抗体反应期。然后，存活患者的免疫球蛋白产生明显恢复至基线或更高水平。然而，抗体反应持续受抑制的患者发生了致命性败血症。在进行的78次检测中，有10次背景（自发）免疫球蛋白合成显著高于正常范围。有丝分裂原诱导的免疫球蛋白产生的这些变化与MLR中T细胞同种异体反应性的变化密切相关。因此，患者体液反应中与热损伤相关的变化可能是T细胞区室（尤其是辅助性T细胞亚群）内变化的结果。
