Smith J A, Haynes T H, Middleton R G
J Urol. 1984 Apr;131(4):705-7. doi: 10.1016/s0022-5347(17)50590-x.
Sixty-four patients with adenocarcinoma of the prostate and histologic evidence of pelvic nodal metastasis have been followed for at least 5 years after pelvic lymphadenectomy only. Forty-seven patients were treated with extended field irradiation, while 17 did not receive any irradiation. Only 17 per cent of the patients receiving irradiation survived free of disease for 5 years, while 40 per cent died of prostatic cancer, compared to 29 and 35 per cent, respectively, of those who did not receive irradiation. Symptomatic manifestations of local disease occurred within 5 years in 65 per cent of the patients not treated with irradiation, compared to 51 per cent of those who received pelvic irradiation. External radiation therapy imparted no discernible benefit in terms of survival free of disease in our patients. Furthermore, the impact of irradiation in preventing local symptoms in these patients seems to be slight.
64例前列腺腺癌且有盆腔淋巴结转移组织学证据的患者仅在盆腔淋巴结清扫术后随访至少5年。47例患者接受了扩大野照射，而17例未接受任何照射。接受照射的患者中只有17%在5年内无病生存，而40%死于前列腺癌，相比之下，未接受照射的患者这两个比例分别为29%和35%。未接受照射的患者中有65%在5年内出现局部疾病的症状表现，而接受盆腔照射的患者这一比例为51%。在我们的患者中，体外放射治疗在无病生存方面没有明显益处。此外，照射在预防这些患者局部症状方面的作用似乎很小。
