Boileau M A, Dowling R A, Gonzales M, Handel P H, Benson G S, Corriere J N
Division of Urology, University of Texas Medical School, Houston 77030.
J Urol. 1988 May;139(5):985-8. doi: 10.1016/s0022-5347(17)42739-x.
We treated 65 patients with prostatic cancer confined clinically to the prostate or periprostatic area during an 8-year period. Seven patients had stage A2, 38 stage B and 20 stage C disease. All 65 patients underwent staging pelvic lymphadenectomy and implantation of gold grains into the prostate (mean dose 3,167 rad). A total of 64 patients then completed a course of external beam irradiation to a mean total tumor dose of 6,965 rad. Complications of therapy were mild and limited (less than 3 months in duration) in most patients, and they included radiation cystitis (32 per cent), diarrhea (31 per cent), extremity lymphedema (7.7 per cent) and wound infection (3 per cent). Two patients suffered urinary incontinence after therapy and 2 (3 per cent) had diarrhea more than 3 months in duration. The actuarial 5-year survival rate for all patients was 87 per cent and the 5-year survival free of disease was 72 per cent.
在8年期间，我们对65例临床诊断为前列腺癌局限于前列腺或前列腺周围区域的患者进行了治疗。7例患者为A2期，38例为B期，20例为C期。所有65例患者均接受了盆腔淋巴结清扫术，并将金粒植入前列腺（平均剂量3167拉德）。然后，共有64例患者完成了外照射疗程，平均总肿瘤剂量为6965拉德。大多数患者的治疗并发症轻微且持续时间有限（少于3个月），包括放射性膀胱炎（32%）、腹泻（31%）、肢体淋巴水肿（7.7%）和伤口感染（3%）。2例患者治疗后出现尿失禁，2例（3%）腹泻持续时间超过3个月。所有患者的精算5年生存率为87%，无病5年生存率为72%。
