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孕酮和雌激素处理对鸡输卵管孕酮受体浓度的增强作用。

Augmentation of progesterone receptor concentration by progesterone and estrogen treatments in the chick oviduct.

作者信息

Ylikomi T, Isola J, Ratia J, Vähä-Tahlo T, Tuohimaa P

出版信息

J Steroid Biochem. 1984 Jan;20(1):445-7. doi: 10.1016/0022-4731(84)90251-6.

DOI:10.1016/0022-4731(84)90251-6
PMID:6708528
Abstract

Cytosol receptors for progesterone in the chick oviduct were measured by charcoal-adsorption assay by using ORG 2058 as a ligand after long-term administration of progesterone and diethylstilbestrol (DES). Steroid administration was carried out by using daily injections or silastic capsules. DES treatment increased the progesterone receptor concentration (from 11500 to 21500 sites per cell, day 14). Progesterone also augmented the concentration of its own receptors (from 11500 to 29000 sites per cell, day 14). In the experiments with capsule administration the same trend was seen. This indicates that both diethylstilbestrol and progesterone are able to increase the concentration of progesterone specific cytosol receptors in the non-differentiated chick oviduct.

摘要

在长期给予孕酮和己烯雌酚(DES)后,使用ORG 2058作为配体,通过活性炭吸附测定法测量雏鸡输卵管中孕酮的胞质溶胶受体。通过每日注射或硅橡胶胶囊进行类固醇给药。DES处理增加了孕酮受体浓度(第14天,从每细胞11500个位点增加到21500个位点)。孕酮也增加了其自身受体的浓度(第14天,从每细胞11500个位点增加到29000个位点)。在胶囊给药的实验中也观察到相同趋势。这表明己烯雌酚和孕酮都能够增加未分化雏鸡输卵管中孕酮特异性胞质溶胶受体的浓度。

相似文献

1
Augmentation of progesterone receptor concentration by progesterone and estrogen treatments in the chick oviduct.孕酮和雌激素处理对鸡输卵管孕酮受体浓度的增强作用。
J Steroid Biochem. 1984 Jan;20(1):445-7. doi: 10.1016/0022-4731(84)90251-6.
2
Estrogen regulation of the biological activity of the avian oviduct progesterone receptor and its ability to induce avidin.雌激素对鸟类输卵管孕酮受体生物活性及其诱导抗生物素蛋白能力的调节
Endocrinology. 1986 Sep;119(3):1118-25. doi: 10.1210/endo-119-3-1118.
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Progesterone down-regulation of nuclear estrogen receptor: a fundamental mechanism in birds and mammals.孕酮对核雌激素受体的下调作用:鸟类和哺乳动物中的一种基本机制。
Gen Comp Endocrinol. 1988 Dec;72(3):443-52. doi: 10.1016/0016-6480(88)90167-0.
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Regulation of nuclear binding of the avian oviduct progesterone receptor. Changes during estrogen-induced oviduct development, withdrawal, and secondary stimulation.禽输卵管孕酮受体的核结合调节。雌激素诱导的输卵管发育、消退和二次刺激过程中的变化。
J Biol Chem. 1984 Feb 25;259(4):2411-21.
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Binding of progesterone with the oviduct cytosol fraction of estrogen-primed quail (Coturnix coturnix japonica).孕酮与雌激素预处理鹌鹑(日本鹌鹑)输卵管胞质部分的结合。
Gen Comp Endocrinol. 1984 Jan;53(1):17-27. doi: 10.1016/0016-6480(84)90220-x.
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Identification of two forms of progesterone receptor from chick oviduct cytosol using non-denaturing gel electrophoresis.使用非变性凝胶电泳从鸡输卵管胞质溶胶中鉴定出两种形式的孕酮受体。
J Steroid Biochem. 1986 Apr;24(4):787-93. doi: 10.1016/0022-4731(86)90438-3.
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Effect of estrogen on gene expression in the chick oviduct. Correlation between nuclear-bound estrogen receptor and chromatin initiation site for transcription.雌激素对鸡输卵管基因表达的影响。核结合雌激素受体与转录染色质起始位点之间的相关性。
J Biol Chem. 1976 Jan 25;251(2):516-23.
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Progesterone downregulates progesterone receptor, but not estrogen receptor, in the estrogen-primed oviduct of a turtle (Trachemys scripta).在雌激素预处理的龟(滑龟)输卵管中,孕酮可下调孕酮受体,但不会下调雌激素受体。
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Progesterone receptors in the chick oviduct. Determination of the total concentration of binding sites in the cytosol and nuclear fraction and effect of progesterone on their distribution.鸡输卵管中的孕酮受体。细胞溶质和细胞核部分结合位点总浓度的测定以及孕酮对其分布的影响。
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Evidence for separate binding sites for progesterone and RU486 in the chick oviduct.
Biochim Biophys Acta. 1986 Nov 28;889(2):192-9. doi: 10.1016/0167-4889(86)90104-7.

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