Weimer D A, Donegan W L
Department of Surgery, Medical College of Wisconsin, Milwaukee.
Breast Cancer Res Treat. 1987 Dec;10(3):273-8. doi: 10.1007/BF01805764.
This study was undertaken to determine if hormone receptor activity in breast cancers changes during different phases of the menstrual cycle. Estrogen (ER) and progesterone (PgR) receptors in seventy-eight primary breast carcinomas from premenopausal women were compared with the phase of the menstrual cycle at the time of biopsy. The frequency of ER positivity did not change, but PgR positivity became significantly higher after the early follicular phase. An increase in mean ER and PgR concentration was found (p less than .05) in the late luteal phase. The results indicate that tumor ER and PgR values change during the menstrual cycle, probably in response to endogenous hormonal fluctuations, and this may account for some vicissitudes in establishing hormone dependence.
本研究旨在确定乳腺癌中的激素受体活性在月经周期的不同阶段是否会发生变化。对78例绝经前女性原发性乳腺癌中的雌激素（ER）和孕激素（PgR）受体与活检时的月经周期阶段进行了比较。ER阳性率没有变化，但在卵泡早期之后，PgR阳性率显著升高。在黄体晚期发现平均ER和PgR浓度有所增加（p小于0.05）。结果表明，肿瘤ER和PgR值在月经周期中会发生变化，可能是对内源性激素波动的反应，这可能解释了在确定激素依赖性方面的一些变化。
