Kato J, Onouchi T, Takamatsu M
J Steroid Biochem. 1984 Apr;20(4A):817-9.
The effects of neonatal hypothyroidism were examined on the concentrations of cytosol receptors for progestin and estrogen in the cytosols from 10-day old female and male rats. The concentration of cytosol progestin- and estrogen receptors in the 10-day old female and male rats with propylthiouracil-induced hypothyroidism was determined by multiconcentration saturation analysis. Neonatal hypothyroidism markedly depressed the level of progestin receptors in the cortex but not in the hypothalamus-preoptic area (HPOA). There were no differences in the concentration of estrogen receptors in the cortex and HPOA between the control and PTU rats. These results suggest that thyroid hormone may be one of the factors affecting the development of progestin receptors in the cortex. Its significance was discussed in relation to determination of the length of sexual differentiation of the rat brain.
研究了新生期甲状腺功能减退对10日龄雌性和雄性大鼠细胞溶质中孕激素和雌激素受体浓度的影响。通过多浓度饱和分析测定了用丙硫氧嘧啶诱导甲状腺功能减退的10日龄雌性和雄性大鼠细胞溶质中孕激素和雌激素受体的浓度。新生期甲状腺功能减退显著降低了皮质中孕激素受体的水平，但下丘脑视前区（HPOA）中未降低。对照组和丙硫氧嘧啶处理组大鼠的皮质和HPOA中雌激素受体浓度没有差异。这些结果表明，甲状腺激素可能是影响皮质中孕激素受体发育的因素之一。并结合大鼠脑性分化长度的测定对其意义进行了讨论。
