Su Chang, Rybalchenko Nataliya, Schreihofer Derek A, Singh Meharvan, Abbassi Babak, Cunningham Rebecca L
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107 USA.
J Steroids Horm Sci. 2012;S2. doi: 10.4172/2157-7536.s2-003.
To date many aspects of neurons and glia biology remain elusive, due in part to the cellular and molecular complexity of the brain. In recent decades, cell models from different brain areas have been established and proven invaluable toward understanding this complexity. In the field of steroid hormone neurobiology, an important question is: what is the profile of steroid hormone receptor expression in these specific cell lines? Currently, a clear summary of such receptor profiling is lacking. For this reason, we summarized in this review the expression of estrogen, progesterone, and androgen receptors in several widely used cell lines (glial and neuronal) derived from the forebrain and midbrain, based on our own data and that from the literature. Such information will aid in the selection of specific cell lines used to test hypotheses related to the biology of estrogens, progestins, and/or androgens.
迄今为止，神经元和神经胶质生物学的许多方面仍然难以捉摸，部分原因在于大脑的细胞和分子复杂性。近几十年来，已建立了来自不同脑区的细胞模型，并证明这些模型对于理解这种复杂性非常宝贵。在类固醇激素神经生物学领域，一个重要问题是：这些特定细胞系中类固醇激素受体的表达情况如何？目前，缺乏对这种受体分析的清晰总结。因此，在本综述中，我们基于自己的数据以及文献数据，总结了从前脑和中脑衍生的几种广泛使用的细胞系（神经胶质细胞系和神经元细胞系）中雌激素、孕激素和雄激素受体的表达情况。此类信息将有助于选择用于检验与雌激素、孕激素和/或雄激素生物学相关假设的特定细胞系。
