Ostermeyer J, Breithardt G, Borggrefe M, Godehardt E, Seipel L, Bircks W
J Thorac Cardiovasc Surg. 1984 Apr;87(4):517-25.
Forty consecutive patients underwent electrophysiologically guided encircling endocardial ventriculotomy as treatment for recurrent sustained ventricular tachycardia resulting from coronary artery disease and previous myocardial infarction. Twelve patients (30%, Group I) had a complete encircling endocardial ventriculotomy and 28 (70%, Group II) had a partial encircling endocardial ventriculotomy (54.4% +/- 2.2% of the left ventricular endocardial circumference) at the earliest electrical activation during ventricular tachycardia. There were no significant differences between the two groups in age, sex ratio, New York Heart Association class, coronary disease, aneurysm location, concomitant bypass grafting, and left ventricular function. One patient of Group I and two patients of Group II did not survive the perioperative period (8% versus 7%, not significant). The survivors were restudied electrophysiologically about 3 weeks after the operation. Eight patients of Group I and 19 patients of Group II were free of ventricular tachycardia (no spontaneous or inducible ventricular tachycardia) without antiarrhythmic drugs (73% versus 73%, not significant). The mean follow-up period in Group I is 22.6 months and in Group II, 15.2 months. Five patients of Group I and of Group II developed severe left ventricular dysfunction (46% versus 8%; p = 0.025). Also, congestive heart failure was a significant cause of death in Group I patients (p = 0.036). In conclusion, electrophysiologically guided partial encircling endocardial ventriculotomy is highly efficient as a surgical treatment of recurrent sustained ventricular tachycardia. Complete encircling endocardial ventriculotomy offers no better ablation of arrhythmias and should be avoided because of its apparent hazards to left ventricular performance.
连续40例患者接受了电生理指导下的环行心内膜心室切开术,以治疗由冠状动脉疾病和既往心肌梗死导致的复发性持续性室性心动过速。12例患者(30%,I组)进行了完全环行心内膜心室切开术,28例患者(70%,II组)在室性心动过速最早电激动时进行了部分环行心内膜心室切开术(占左心室心内膜周长的54.4%±2.2%)。两组在年龄、性别比例、纽约心脏协会分级、冠心病、动脉瘤位置、同期搭桥手术和左心室功能方面无显著差异。I组1例患者和II组2例患者围手术期死亡(8%对7%,无显著性差异)。术后约3周对存活患者进行了电生理复查。I组8例患者和II组19例患者在未使用抗心律失常药物的情况下无室性心动过速(无自发或可诱发的室性心动过速)(73%对73%,无显著性差异)。I组平均随访期为22.6个月,II组为15.2个月。I组和II组各有5例患者发生严重左心室功能障碍(46%对8%;p=0.025)。此外,充血性心力衰竭是I组患者死亡的重要原因(p=0.036)。总之,电生理指导下的部分环行心内膜心室切开术作为复发性持续性室性心动过速的外科治疗方法效率很高。完全环行心内膜心室切开术在心律失常消融方面并无更好效果,且因其对左心室功能有明显危害应避免使用。