Wetstein L, Michelson E L, Moore E N, Harken A H
J Thorac Cardiovasc Surg. 1984 Apr;87(4):571-6.
Ventricular tachyarrhythmias are common sequelae of ischemic myocardial damage. To assess the susceptibility to sustained ventricular tachycardia in a canine model in which endocardial excision was performed, 30 adult mongrel dogs were divided into three groups and studied in an open-chest condition, anesthetized under pentobarbital anesthesia, 7 to 14 days after undergoing one of three alternative procedures: (Group A) sham-operated controls, 10 dogs; (Group B) left ventricular endocardial excision, 10 dogs; and (Group C) myocardial infarction produced by a 2-hour occlusion and subsequent reperfusion of the left anterior descending coronary artery, 10 dogs. Using programmed ventricular pacing with two extrastimuli via plunge electrodes at 10 normal sites in the distribution of the left anterior descending coronary artery in each dog, sustained ventricular tachycardia was induced in 0/10 Group A dogs at 0/100 sites and in 0/10 Group B dogs at 0/100 sites; in contrast, in Group C, 7/10 (70%, p less than 0.01) dogs had inducible sustained ventricular tachycardia and at 39/70 (56%, p less than 0.001) sites. Thus, 7 to 14 days following endocardial excision, dogs are no more susceptible to the initiation of sustained ventricular tachycardia than are sham-operated control animals. This is in contrast to dogs with chronic heterogeneous infarctions (Group C) due to coronary occlusion and reperfusion, which are highly susceptible to ventricular tachycardia initiation.
室性快速心律失常是缺血性心肌损伤常见的后遗症。为了评估在进行心内膜切除的犬模型中发生持续性室性心动过速的易感性，将30只成年杂种犬分为三组，并在开胸状态下进行研究，戊巴比妥麻醉，在接受以下三种替代手术之一7至14天后：（A组）假手术对照组，10只犬；（B组）左心室心内膜切除，10只犬；（C组）通过左前降支冠状动脉闭塞2小时并随后再灌注产生心肌梗死，10只犬。通过在每只犬的左前降支冠状动脉分布的10个正常部位使用经穿刺电极进行双期外刺激的程序性心室起搏，A组10只犬中0/100个部位未诱发出持续性室性心动过速，B组10只犬中0/100个部位未诱发出持续性室性心动过速；相比之下，在C组中，7/10（70%，p<0.01）只犬可诱发出持续性室性心动过速，在39/70（56%，p<0.001）个部位可诱发出持续性室性心动过速。因此，心内膜切除术后7至14天，犬对持续性室性心动过速的起始并不比假手术对照动物更易感。这与因冠状动脉闭塞和再灌注导致慢性异质性梗死的犬（C组）形成对比，后者对室性心动过速的起始高度易感。
