Sotelo J, Escobedo F, Rodriguez-Carbajal J, Torres B, Rubio-Donnadieu F
N Engl J Med. 1984 Apr 19;310(16):1001-7. doi: 10.1056/NEJM198404193101601.
Twenty-six patients with cysticercosis of the brain parenchyma were treated with the antihelmintic agent praziquantel (50 mg per kilogram of body weight daily for 15 days). During treatment a strong inflammatory reaction occurred, as evidenced by increased protein and cells in the cerebrospinal fluid. This finding correlated with headache, exacerbation of neurologic symptoms, and edema and inflammation around cystic lesions. After three months of treatment all patients had improved clinically, and 13 (50 per cent) were asymptomatic. The total number of cysts on CT scans had decreased from 152 at the beginning of treatment to 51, and the mean diameter of cysts was reduced by 72 per cent. CT scans showed improvement in 25 of the 26 patients, with total remission of all cysts in nine. Seventeen control patients followed with CT studies for a mean of 9 +/- 2 months had no spontaneous remission of lesions, and in many cases the scans showed worsening during the observation period. Our results indicate that praziquantel is effective in cysticercosis of the brain parenchyma.
26例脑实质囊尾蚴病患者接受了抗蠕虫药吡喹酮治疗（每日每千克体重50毫克，共15天）。治疗期间出现了强烈的炎症反应，脑脊液中的蛋白质和细胞增多证明了这一点。这一发现与头痛、神经症状加重以及囊性病变周围的水肿和炎症相关。治疗三个月后，所有患者临床症状均有改善，13例（50%）无症状。CT扫描显示囊肿总数从治疗开始时的152个减少到51个，囊肿平均直径缩小了72%。CT扫描显示26例患者中有25例病情改善，9例囊肿完全消失。17例对照患者接受CT研究，平均随访9±2个月，病变无自发缓解，在许多病例中，扫描显示观察期内病情恶化。我们的结果表明，吡喹酮对脑实质囊尾蚴病有效。
