Chan H S, Becker L E, Hoffman H J, Humphreys R P, Hendrick E B, Fitz C R, Chuang S H
Neurosurgery. 1984 Feb;14(2):204-10. doi: 10.1227/00006123-198402000-00015.
Seven of fourteen children with spinal cord ependymoma had myxopapillary tumors of the filum terminale. These tumors made up 15.9% of all primary spinal neuroectodermal tumors in children (44 cases) seen during a 62-year period (1919 to 1981). Their clinical presentation, radiological features, pathological findings, treatment, and outcome are reported. Six of the seven patients were known to be alive at the time of writing. The seventh patient was lost to follow-up after 3 years without tumor recurrence. Of 5 patients whose primary mode of treatment was operation alone. 3 had intraspinal or intracranial recurrences. Despite tumor recurrences, 2 patients were long term survivors after further operation and irradiation, whereas the third patient recently received craniospinal irradiation for intracranial tumor recurrence. The 2 patients who did not have tumor recurrence after operation alone had been followed for 3 and 7 years, respectively. Two children with subtotal tumor resection and spinal irradiation had no recurrences at 1 and 17 years, respectively. Our data suggest that this unusual subtype of spinal ependymoma is not uncommon during childhood and has a good prognosis. All patients with this tumor require prolonged follow-up for tumor recurrence after operation and irradiation.
14例脊髓室管膜瘤患儿中有7例患有终丝黏液乳头型肿瘤。在62年期间（1919年至1981年）所见的儿童原发性脊髓神经外胚层肿瘤（44例）中，这些肿瘤占15.9%。报告了它们的临床表现、放射学特征、病理结果、治疗及预后。撰写本文时已知7例患者中有6例存活。第7例患者在3年后失访，无肿瘤复发。5例主要治疗方式为单纯手术的患者中，3例出现脊髓内或颅内复发。尽管肿瘤复发，但2例患者在进一步手术和放疗后长期存活，而第3例患者最近因颅内肿瘤复发接受了全脑全脊髓放疗。单纯手术后未出现肿瘤复发的2例患者分别随访了3年和7年。2例肿瘤次全切除并接受脊髓放疗的患儿分别在1年和17年时未出现复发。我们的数据表明，这种不常见的脊髓室管膜瘤亚型在儿童期并不罕见，且预后良好。所有患有这种肿瘤的患者术后和放疗后都需要长期随访以监测肿瘤复发。
