McNairy Scott L, Maruta Toshihiko, Ivnik Robert J, Swanson David W, Ilstrup Duane M
Department of Psychiatry and Psychology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905 U.S.A. Department of Medical Statistics and Epidemiology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905 U.S.A.
Pain. 1984 Feb;18(2):169-177. doi: 10.1016/0304-3959(84)90884-4.
The abuse of prescription drugs is an insidious complication among patients with chronic pain. This study examines cognitive intellectual functions in patients with chronic pain who are using prescribed analgesics, sedatives and hypnotics. A comprehensive battery of psychologic tests measuring intelligence, learning, memory, sensory-perceptual integrity, motor skills and general adaptive abilities was administered to 47 subjects. The subjects were patients admitted to a chronic pain management program, and they were divided into drug-dependent, drug-abusing and non-drug-abusing groups according to strictly defined criteria. Findings indicated that the prescribed use of these medications for pain over a prolonged time is detrimental to the cognitive function of such patients and complicates their clinical management.
处方药滥用是慢性疼痛患者中一种潜伏性的并发症。本研究调查了正在使用处方镇痛药、镇静剂和催眠药的慢性疼痛患者的认知智力功能。对47名受试者进行了一系列全面的心理测试，以测量智力、学习、记忆、感觉-知觉完整性、运动技能和一般适应能力。受试者为入住慢性疼痛管理项目的患者，根据严格定义的标准将他们分为药物依赖组、药物滥用组和非药物滥用组。研究结果表明，长期将这些药物用于止痛对这类患者的认知功能有害，并使其临床管理复杂化。
