Paxton J W
Pharmacology. 1984;28(2):86-9. doi: 10.1159/000137947.
The effect of probenecid on the plasma protein binding of methotrexate (MTX) has been examined in vitro. At concentrations greater than or equal to 5 x 10(-4) M, probenecid caused a significant reduction (greater than 30%) in the plasma binding of MTX. It is suggested that in vivo this would lead to a greater dispersion into the tissues and a larger volume of distribution, and may be partly responsible for the longer MTX elimination half-life observed with concurrent administration of probenecid.
已在体外研究了丙磺舒对甲氨蝶呤（MTX）血浆蛋白结合的影响。当丙磺舒浓度大于或等于5×10⁻⁴ M时，它会导致MTX的血浆结合率显著降低（超过30%）。据推测，在体内这将导致更多药物分散到组织中，分布容积增大，这可能是同时给予丙磺舒时观察到MTX消除半衰期延长的部分原因。
