丙磺舒对血清甲氨蝶呤浓度的延长及增强作用。
Prolongation and enhancement of serum methotrexate concentrations by probenecid.
作者信息
Aherne G W, Piall E, Marks V, Mould G, White W F
出版信息
Br Med J. 1978 Apr 29;1(6120):1097-9. doi: 10.1136/bmj.1.6120.1097.
Abstract
The disappearance of methotrexate (MTX) from the serum after an intravenous bolus injection and intravenous infusion was studied over 24 hours in eight and four patients respectively. Probenecid given at the same time as the bolus injection delayed the disappearance of MTX from the serum and resulted in enhanced concentrations throughout the 24 hours studied. At 24 hours the mean concentration was four times higher than in patients not given probenecid. Overall serum concentrations were even greater than those in patients who had received MTX by intravenous infusion. We suggest that smaller doses of MTX may be given and treatment costs thereby reduced if probenecid is given in addition.
摘要
分别对8例和4例患者进行研究，观察静脉推注和静脉输注甲氨蝶呤（MTX）后24小时内其在血清中的消失情况。推注MTX时同时给予丙磺舒，可延缓MTX在血清中的消失，并导致在整个24小时研究期间浓度升高。24小时时，平均浓度比未给予丙磺舒的患者高4倍。总体血清浓度甚至高于接受MTX静脉输注的患者。我们建议，如果同时给予丙磺舒，可减少MTX的给药剂量，从而降低治疗成本。
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