Zalikin G A, Moskalev Iu I, Nisimov V G
Radiobiologiia. 1984 Jan-Feb;24(1):122-5.
A study was made of the kinetics of metabolism and distribution of 249Bk within the albino rat body. After the intraperitoneal administration of 249Bk nitrate, the radionuclide circulated with blood for a long time and was deposited mainly in the skeleton (up to 39.8% of the quantity administered) and liver (18.4%). The radionuclide concentrations in the adrenal glands, liver, spleen, kidneys and osseous tissue were 7.3, 3.2, 1.3, 1.1, and 1.2%, respectively, of the quantity administered per 1 g of fresh tissue. 249Bk was mainly excreted in urea. During 30 days of observation 18.2% and 10.4%, of the quantity administered, were excreted in urea and feces, respectively.
对白化大鼠体内249锫的代谢动力学和分布情况进行了研究。腹腔注射硝酸249锫后,该放射性核素在血液中长时间循环,主要沉积在骨骼(高达给药量的39.8%)和肝脏(18.4%)中。每1克新鲜组织中,肾上腺、肝脏、脾脏、肾脏和骨组织中的放射性核素浓度分别为给药量的7.3%、3.2%、1.3%、1.1%和1.2%。249锫主要通过尿液排出。在30天的观察期内,给药量的18.2%和10.4%分别通过尿液和粪便排出。