Poverennyĭ A M, Semina O V, Semenets T N, Ivanov V K, Shapovalova E V
Radiobiologiia. 1984 Jan-Feb;24(1):39-43.
It was shown that the dose--effect curves describing the radiosensitivity of CFUc of the bone marrow irradiated in vitro (0.04-3.7 Gy) and treated with normal rabbit serum (NRS) and anti-mouse-brain serum (AMBS) has two differently sloping portions indicating that two CFUc populations differing in radiosensitivity are present in the bone marrow. D0 was 0.93 Gy after irradiation with doses of 0.04-0.75 Gy and treatment with NRS, and 0.33 Gy after incubation of the bone marrow with AMBS. The addition of thymus cells "straightened" the dose--effect curve for the bone marrow treated with AMBS: in this case D0 was 1.81 Gy exceeding considerably the values of D0 for intact bone marrow. The CFUc population is suggested to be heterogeneous in radiosensitivity.
结果表明，描述体外照射（0.04 - 3.7 Gy）并用正常兔血清（NRS）和抗小鼠脑血清（AMBS）处理的骨髓CFUc放射敏感性的剂量 - 效应曲线有两个斜率不同的部分，这表明骨髓中存在两个放射敏感性不同的CFUc群体。在用0.04 - 0.75 Gy剂量照射并用NRS处理后，D0为0.93 Gy，在用AMBS孵育骨髓后，D0为0.33 Gy。加入胸腺细胞使用AMBS处理的骨髓的剂量 - 效应曲线“变直”：在这种情况下，D0为1.81 Gy，大大超过完整骨髓的D0值。提示CFUc群体在放射敏感性方面是异质的。
