Semenets T N, Semina O V, Kurilets E S, Poverennyĭ A M
Radiobiologiia. 1986 Jul-Aug;26(4):553-7.
With hydroxyurea injected to donor mice a greater inhibition of splenic colony growth occurred after incubation of a bone marrow suspension with the rabbit antimouse brain serum (RAMBS), and restoration of the colony-formation by thymocytes was less pronounced than in normal bone marrow treated with the antibrain serum. The incubation of the bone marrow cells containing CFUc, which actively proliferate after irradiation or stimulation by vinblastine, with the antibrain serum sharply suppressed the splenic colony growth. In this case however, in contrast to normal bone marrow, the administration of thymocytes failed to exert a favourable action on the colony formation. It is suggested that functioning of accessory cells is not associated with the defined cell cycle stage of CFUc and that, in addition to the previously discovered accessory cell population, some other factors, inactivated by the RAMBS serum, are present in the bone marrow the analogue of which is absent in the thymus.
给供体小鼠注射羟基脲后，将骨髓悬液与兔抗小鼠脑血清（RAMBS）孵育，脾集落生长受到更大抑制，且胸腺细胞对集落形成的恢复作用不如用抗脑血清处理的正常骨髓明显。含有集落形成单位 - 粒细胞（CFUc）的骨髓细胞在照射或长春碱刺激后会积极增殖，将其与抗脑血清孵育会显著抑制脾集落生长。然而在这种情况下，与正常骨髓不同，给予胸腺细胞对集落形成未发挥有利作用。这表明辅助细胞的功能与CFUc的特定细胞周期阶段无关，并且除了先前发现的辅助细胞群体外，骨髓中还存在一些被RAMBS血清灭活的其他因素，而胸腺中不存在类似物。
