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[暴露于快中子和γ射线后大鼠胸腺染色质断裂的特征]

[Characteristics of chromatin breakdown in the rat thymus after exposure to fast neutrons and gamma rays].

作者信息

Vodolazskaia N A

出版信息

Radiobiologiia. 1984 Jan-Feb;24(1):66-9.

PMID:6709845
Abstract

A comparative study was made of the radiobiological aftereffects of the action of fast neutrons and gamma-rays on lymphoid tissues of rat thymus with a reference to a biochemical criterion of the interphase death of lymphocytes, i.e. the formation of polydeoxynucleotides (PDN). It was shown that the increase in the chromatin degradation was a function of dose of neutron- and gamma-radiation (up to 4 Gy). The dynamics of the PDN formation was similar with both types of radiation, but 4-6 h after neutron irradiation chromatin degradation was higher more pronounced. The RBE of neutrons varied from 3 to 2 with a radiation dose varying from 0.25 to 4 Gy.

摘要

对快中子和γ射线作用于大鼠胸腺淋巴组织的放射生物学后效应进行了比较研究,以淋巴细胞间期死亡的生化标准,即多脱氧核苷酸(PDN)的形成为参考。结果表明,染色质降解的增加是中子和γ辐射剂量(高达4 Gy)的函数。两种辐射下PDN形成的动力学相似,但中子照射后4 - 6小时染色质降解更高且更明显。中子的相对生物效应(RBE)在辐射剂量从0.25到4 Gy变化时从3变化到2。

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