[亚铁离子和γ射线诱导的脂质过氧化对线粒体呼吸及氧化磷酸化的影响]
[Effect of Fe2+- and gamma-induced lipid peroxidation on respiration and oxidative phosphorylation in the mitochondria].
作者信息
Seĭlanov A S, Popov G A, Konev V V
出版信息
Radiobiologiia. 1984 Jan-Feb;24(1):81-3.
PMID:6709850
Abstract
Lipid peroxidation activated by low concentrations of Fe2+ ions in a medium (1-5 microM) and gamma-quanta (10-50 Gy) stimulates the oxygen consumption and oxidative phosphorylation during the initial period of incubation (10-20 min). With relatively high concentrations of Fe2+ ions and higher radiation doses (50-100 Gy) inhibition of the activity of mitochondria is registered with respect to both indices.
摘要
在培养基中低浓度的Fe2+离子（1 - 5微摩尔）和γ量子（10 - 50戈瑞）激活的脂质过氧化作用，在孵育初期（10 - 20分钟）刺激氧气消耗和氧化磷酸化。对于较高浓度的Fe2+离子和更高的辐射剂量（50 - 100戈瑞），线粒体活性在这两个指标方面均表现出抑制作用。
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