Petersen B, Christiansen J, Rökaeus A, Rosell S
Scand J Gastroenterol. 1984 Jan;19(1):48-51.
The effects of intrajejunal and intravenous infusion of fat (100 ml Intralipid 20%) on pentagastrin-stimulated gastric acid secretion and on the concentrations of plasma neurotensin-like immunoreactivity (p-NTLI) were studied in eight healthy subjects. Gastric acid secretion was studied for a 1.5-h period at 15-min intervals after fat administration. Acid secretion was reduced by 58% and 36%, respectively, after intrajejunal and intravenous administration. The concentration of p-NTLI rose significantly from 29 to 177 pmol/l at 45 min after intrajejunal administration but did not change after intravenous infusion. The results indicate that large volumes of fat inhibit gastric acid secretion by a neurotensin-independent postabsorptive mechanism and by an intestinal mechanism that may in part be mediated by neurotensin.
在8名健康受试者中，研究了空肠内和静脉输注脂肪（100ml 20%英脱利匹特）对五肽胃泌素刺激的胃酸分泌以及血浆神经降压素样免疫反应性（p-NTLI）浓度的影响。在给予脂肪后，以15分钟的间隔对胃酸分泌进行了1.5小时的研究。空肠内和静脉给药后，胃酸分泌分别减少了58%和36%。空肠内给药后45分钟，p-NTLI浓度从29pmol/l显著升至177pmol/l，但静脉输注后未发生变化。结果表明，大量脂肪通过一种不依赖神经降压素的吸收后机制和一种可能部分由神经降压素介导的肠道机制抑制胃酸分泌。
