Christiansen J, Rehfeld J F, Stadil F
Scand J Gastroenterol. 1976;11(7):673-6.
The effect of intrajejunal fat infusion on meal-stimulated gastric acid and gastrin secretion was studied in 8 healthy volunteers. Intrajejunal fat significantly reduced the acid response to a meal, measured by intragastric titration, as compared to intrajejunal infusion of saline. While serum gastrin concentrations rose from fasting levels to a constant plateau after the meal when saline was infused, fat infusion resulted in a transitory decrease in serum gastrin concentration followed by a significant increase. It is concluded that inhibition of gastrin release only plays a minor role, if any, in the observed fat-induced jejuanl inhibition of meal-stimulated acid secretion.
在8名健康志愿者中研究了空肠内输注脂肪对进餐刺激的胃酸和胃泌素分泌的影响。与空肠内输注生理盐水相比，空肠内输注脂肪显著降低了通过胃内滴定法测得的对进餐的酸反应。当输注生理盐水时，餐后血清胃泌素浓度从空腹水平升至恒定平台期，而输注脂肪则导致血清胃泌素浓度短暂下降，随后显著升高。得出的结论是，在观察到的脂肪诱导的空肠对进餐刺激的酸分泌的抑制中，胃泌素释放的抑制即使有作用，也只起次要作用。
