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委内瑞拉美洲印第安人和混血裔多产妇女血清中的细胞毒性抗体。

Cytotoxic antibodies in sera of Venezuelan multiparous women of Amerindian and mixed ethnic origin.

作者信息

Simonney N, Layrisse Z, Balbas O, García E, Stoikow Z

出版信息

Tissue Antigens. 1984 Feb;23(2):117-26. doi: 10.1111/j.1399-0039.1984.tb00020.x.

DOI:10.1111/j.1399-0039.1984.tb00020.x
PMID:6710474
Abstract

Sera from 464 multiparous women of mixed ethnic origin and 114 Amerindian mothers (Warao of Western Venezuela), were studied for lymphocytotoxicity using a panel of B and T lymphocytes isolated from 50 to 100 individuals from the same populations. Twenty-five and 9.65% of the sera, respectively, showed activity against at least 5% of the panel. Among the women of mixed ethnic origin 10% produced antibodies directed against one or more HLA Class I antigens while 2 sera contained monospecific anti-DR antibodies; among the Warao, only 2 sera recognized HLA antigens: a Bw51 and an undetermined Cw antigen which shows linkage disequilibrium with Bw16 in both populations.

摘要

对464名不同种族的经产妇和114名美洲印第安母亲(委内瑞拉西部的瓦劳人)的血清进行了研究,采用从同一人群中50至100人分离出的一组B和T淋巴细胞进行淋巴细胞毒性检测。分别有25%和9.65%的血清对至少5%的细胞组显示出活性。在不同种族的经产妇中,10%产生了针对一种或多种HLA I类抗原的抗体,而2份血清含有单特异性抗DR抗体;在瓦劳人中,只有2份血清识别HLA抗原:一份Bw51和一份未确定的Cw抗原,该抗原在两个群体中均与Bw16存在连锁不平衡。

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