Gupta M, Bagchi G K, Gupta S D, Sasmal D, Chatterjee T, Dey S N
Toxicology. 1984 Mar;30(2):171-5. doi: 10.1016/0300-483x(84)90127-6.
The effects of multiple intraperitoneal doses of Nuvacron (0.8 mg/kg) or Furadan (0.25 mg/kg) on the concentrations of brain neurotransmitters in mice were studied. The following were measured: acetylcholine, acetylcholinesterase, gamma-aminobutyric acid, epinephrine, norepinephrine, dopamine and 5-hydroxytryptamine. These pesticides caused a significant decrease in acetylcholinesterase activity and a significant increase in acetylcholine, gamma-amino-butyric acid, epinephrine, norepinephrine, dopamine and 5-hydroxy tryptamine concentrations. The increased concentrations of the neurotransmitters in mouse brain might be associated with CNS depressant action induced by the insecticides.
研究了多次腹腔注射努瓦克龙（0.8毫克/千克）或呋丹（0.25毫克/千克）对小鼠大脑神经递质浓度的影响。检测了以下指标：乙酰胆碱、乙酰胆碱酯酶、γ-氨基丁酸、肾上腺素、去甲肾上腺素、多巴胺和5-羟色胺。这些杀虫剂导致乙酰胆碱酯酶活性显著降低，乙酰胆碱、γ-氨基丁酸、肾上腺素、去甲肾上腺素、多巴胺和5-羟色胺浓度显著升高。小鼠大脑中神经递质浓度的升高可能与杀虫剂引起的中枢神经系统抑制作用有关。
