Gupta M, Bagchi G, Bandyopadhyay S, Sasmal D, Chatterjee T, Dey S N
Toxicology. 1982;25(2-3):255-60. doi: 10.1016/0300-483x(82)90034-8.
The effects of multiple intraperitoneal doses of Nuvacron (0.8 mg/kg) or Furadan (0.25 mg/kg) on hematological values in mice were studied. The following were measured: clotting time, hemoglobin content, total count of red blood cells and white blood cells, differential count of white blood cells, platelet count, erythrocyte sedimentation rate, hematocrit value, mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration, bone marrow and splenic measurements. These pesticides caused a significant decrease in hemoglobin content, total count of red blood cells, platelet count, erythrocyte sedimentation rate and hematocrit value. The administration of Nuvacron or Furadan prolonged the clotting time and caused an increase in total count of white blood cells. Among white blood cells, there was an increase in neutrophils and basophils and a fall in the count of lymphocytes in treated animals. Bone marrow depression and splenic hyperplasia were observed in mice after administration of the pesticides.
研究了多次腹腔注射努瓦克龙（0.8毫克/千克）或呋哺丹（0.25毫克/千克）对小鼠血液学指标的影响。测定了以下指标：凝血时间、血红蛋白含量、红细胞和白细胞总数、白细胞分类计数、血小板计数、红细胞沉降率、血细胞比容值、平均红细胞体积、平均红细胞血红蛋白含量和平均红细胞血红蛋白浓度、骨髓和脾脏测量值。这些农药导致血红蛋白含量、红细胞总数、血小板计数、红细胞沉降率和血细胞比容值显著降低。注射努瓦克龙或呋哺丹会延长凝血时间，并导致白细胞总数增加。在接受治疗的动物中，白细胞中的中性粒细胞和嗜碱性粒细胞增加，淋巴细胞计数下降。给小鼠注射农药后观察到骨髓抑制和脾脏增生。
