Kondrashova O B, Tsyrlov I B
Vopr Med Khim. 1984 Jan-Feb;30(1):44-8.
A method is developed for studies of differences in peptide structure of native membrane-bound monooxygenases using limited proteolysis of liver microsomal hemoproteins. Analysis of peptide maps was carried out in constitutive and induced by 3 methylcholanthrene and 2, 3, 7, 8-tetrachlorodibenzodioxin enzyme forms, responsible for metabolic and biological activation of polycyclic aromatic hydrocarbons.
一种利用肝脏微粒体血红蛋白的有限蛋白酶解来研究天然膜结合单加氧酶肽结构差异的方法被开发出来。在由3-甲基胆蒽和2,3,7,8-四氯二苯并二恶英诱导的组成型和诱导型酶形式中进行肽图谱分析，这些酶形式负责多环芳烃的代谢和生物活化。
