Stögmann W, Bohrn E
Wien Klin Wochenschr. 1984 Jan 6;96(1):12-6.
A report is presented of a male infant with nephrogenic diabetes insipidus type I. A low-solute-load diet and large fluid intake were not able to prevent hypertonic dehydration and to control the disease. It responded within 3 days to indomethacin (3 mg/kg body weight), a prostaglandin synthetase inhibitor. The boy is doing well on this regimen and no side-effects have been observed after 2 years of treatment. Hitherto only a few case reports have been published on this therapeutic regimen, but all confirm the high efficacy of prostaglandin synthesis inhibition as the treatment of choice in nephrogenic diabetes insipidus.
本文报告了一例患有Ⅰ型肾性尿崩症的男婴。低溶质负荷饮食和大量液体摄入未能预防高渗性脱水及控制病情。该患儿在3天内对吲哚美辛（3毫克/千克体重）——一种前列腺素合成酶抑制剂——产生了反应。在该治疗方案下，患儿情况良好，治疗2年后未观察到副作用。迄今为止，关于这种治疗方案仅发表了少数病例报告，但所有报告均证实前列腺素合成抑制作为肾性尿崩症的首选治疗方法具有很高的疗效。
