Ivanokov A N, Dubrovskaia M K, Karneev A N, Nefedov E P
Zh Nevropatol Psikhiatr Im S S Korsakova. 1984;84(2):185-9.
Study of the amino acid spectrum in the blood plasma of 45 patients with multiple sclerosis (MS) demonstrated marked deaminoacidemia with a tendency toward hypoaminoacidemia in all those studied. Characteristic significant changes in the chromatogram of free amino acids were detected at the stages of rapid and slow disease progression, during disease remissions and at the stage of stabilization. The disclosed disorders of the composition of free amino acids contribute to the better understanding of the disease pathogenesis and may serve as a differential-diagnostic criterion in various forms of the MS course. They also make it possible to outline rational directions in the comprehensive management of MS.
对45例多发性硬化症（MS）患者血浆氨基酸谱的研究表明，所有研究对象均出现明显的脱氨基酸血症，并有低氨基酸血症倾向。在疾病快速进展和缓慢进展阶段、疾病缓解期以及稳定期，均检测到游离氨基酸色谱图有特征性的显著变化。所揭示的游离氨基酸组成紊乱有助于更好地理解疾病发病机制，并可作为MS不同病程形式的鉴别诊断标准。它们还使制定MS综合管理的合理方向成为可能。
