Briksman A M
Zh Nevropatol Psikhiatr Im S S Korsakova. 1984;84(2):189-93.
The study of initial symptoms of disseminated sclerosis in 250 patients showed the disease to manifest mostly by one, less frequently by two or more symptoms. The following symptoms occurred earlier and more frequently than others: locomotor disorders (transient mono- or parapareses); limited paresthesias, hypesthesias and pains; retrobulbar neuritis, transient pareses of ocular muscles; while vestibular, cerebellar and vesicular disorders were encountered less frequently. A definite correlation between the type of onset (mono- or polysymptomatic) and a further clinical course was established. The following criteria are offered for the first attack diagnosis; unsteadiness and reversibility of initial symptoms, frequent detection of clinical dissociations in the initial symptoms structure, spontaneous remissions of different duration between the first and recurrent attacks.
对250例播散性硬化症患者初始症状的研究表明，该疾病大多表现为一种症状，较少表现为两种或更多症状。以下症状比其他症状出现得更早且更频繁：运动障碍（短暂性单瘫或截瘫）；局限性感觉异常、感觉减退和疼痛；球后视神经炎、眼肌短暂性麻痹；而前庭、小脑和膀胱功能障碍则较少见。已确定起病类型（单症状或多症状）与进一步的临床病程之间存在明确关联。为首次发作诊断提供了以下标准：初始症状的不稳定性和可逆性、在初始症状结构中频繁发现临床分离、首次发作和复发发作之间不同持续时间的自发缓解。
