Strøm J, Jansen E C
Acta Anaesthesiol Scand. 1984 Feb;28(1):40-3. doi: 10.1111/j.1399-6576.1984.tb02007.x.
The effect was evaluated of a small "self-taming" dose of suxamethonium (0.1 mg/kg) on fasciculations and postoperative muscle pain following a normal intubating dose of suxamethonium (1.0 mg/kg). Forty outpatients undergoing bronchoscopy were randomly allocated to pretreatment with either sodium chloride or suxamethonium 0.1 mg/kg. The pretreatment dose was followed in 60 s by suxamethonium 1.0 mg/kg. Visual rating and mechanical registration of muscle fasciculations were done separately. Muscle pain was found in 74% and in 26% of the patients following pretreatment with sodium chloride and suxamethonium 0.1 mg/kg, respectively (P less than 0.01). No significant relationship was found between pain and muscle fasciculations. It is concluded that self-taming with suxamethonium has a marked pain-reducing effect; and this technique may be used as an alternative to pretreatment with a non-depolarizing relaxant.
评估了小剂量“自我驯服”的琥珀酰胆碱（0.1毫克/千克）对正常插管剂量琥珀酰胆碱（1.0毫克/千克）后肌束震颤和术后肌肉疼痛的影响。40例接受支气管镜检查的门诊患者被随机分为两组，分别用氯化钠或0.1毫克/千克的琥珀酰胆碱进行预处理。预处理剂量给药60秒后，给予1.0毫克/千克的琥珀酰胆碱。分别对肌束震颤进行视觉评分和机械记录。用氯化钠和0.1毫克/千克琥珀酰胆碱预处理后，肌肉疼痛分别出现在74%和26%的患者中（P小于0.01）。未发现疼痛与肌束震颤之间存在显著关系。得出结论，琥珀酰胆碱自我驯服具有显著的减轻疼痛效果；并且该技术可作为非去极化肌松药预处理的替代方法。
