Magee D A, Gallagher E G
Br J Anaesth. 1984 Sep;56(9):977-80. doi: 10.1093/bja/56.9.977.
Fifty patients undergoing routine surgery were randomly divided into two groups. Group 1 were pretreated with a small (10-mg) dose of suxamethonium ("self-taming") before administration of suxamethonium 1 mg kg-1, while group 2 received no pretreatment. Potassium concentrations were measured immediately before induction of anaesthesia and, subsequently, for 7 min. A small increase in mean plasma potassium concentration was seen in the group who were not pretreated, while the patients who received a "self-taming" dose of suxamethonium showed a sustained decrease below pre-induction values. Mean plasma potassium concentrations were significantly less in the "self-taming" group than in the group not pretreated.
50例接受常规手术的患者被随机分为两组。第1组在给予1mg/kg琥珀胆碱之前，先用小剂量（10mg）琥珀胆碱进行预处理（“自我驯服”），而第2组未接受预处理。在麻醉诱导前即刻测量血钾浓度，随后持续测量7分钟。未接受预处理的组平均血浆钾浓度有小幅升高，而接受“自我驯服”剂量琥珀胆碱的患者血浆钾浓度持续低于诱导前水平。“自我驯服”组的平均血浆钾浓度显著低于未预处理组。
