Koller M E, Breivik H, Greider P, Jones D J, Smith R B
Acta Anaesthesiol Scand. 1984 Feb;28(1):87-90. doi: 10.1111/j.1399-6576.1984.tb02017.x.
The effects of spinal cord transection and acidosis on succinylcholine (SCC)-induced hyperkalemia were studied in Sprague-Dawley rats. The effectiveness of pretreatment with subparalyzing doses ("self-taming") of SCC or with the cholinesterase inhibitor hexafluorenium bromide in preventing hyperkalemia was also studied. The increase in plasma potassium after administration of SCC (1 mg/kg) was found to be significantly increased 10 days after spinal cord transection. This potassium increase could not be prevented by pretreatment with either hexafluorenium (0.3 mg/kg) or subparalyzing doses (0.15 mg/kg) of SCC. Respiratory acidosis caused an increase in plasma K+ in both normal and in spinal cord transected rats. Acidosis had a synergistic effect on succinylcholine-induced hyperkalemia. These findings support the clinical practice of not using succinylcholine in patients at risk of having a pathological sensitivity to SCC. Furthermore, SCC may be especially dangerous when administered to patients who are acidotic.
在斯普拉格-道利大鼠中研究了脊髓横断和酸中毒对琥珀酰胆碱（SCC）诱导的高钾血症的影响。还研究了用低于麻痹剂量（“自我驯化”）的SCC或胆碱酯酶抑制剂溴化六甲铵预处理预防高钾血症的有效性。发现脊髓横断10天后，给予SCC（1mg/kg）后血浆钾的升高显著增加。用溴化六甲铵（0.3mg/kg）或低于麻痹剂量（0.15mg/kg）的SCC预处理均不能预防这种钾升高。呼吸性酸中毒在正常大鼠和脊髓横断大鼠中均导致血浆K+升高。酸中毒对琥珀酰胆碱诱导的高钾血症有协同作用。这些发现支持了在对SCC有病理敏感性风险的患者中不使用琥珀酰胆碱的临床实践。此外，当给予酸中毒患者时，SCC可能特别危险。
