Sollevi A, Lagerkranser M, Andreen M, Irestedt L
Acta Physiol Scand. 1984 Feb;120(2):171-6. doi: 10.1111/j.1748-1716.1984.tb00122.x.
The hemodynamic effects of ATP and adenosine (i.v. infusions) were studied in dogs in parallel with quantitative determination of purines in plasma by HPLC. In two experiments, infusion were performed during treatment with dipyridamole, an uptake inhibitor of adenosine. A 50-60% reduction of mean arterial blood pressure (MABP) was induced by both ATP and adenosine at infusion rates ranging between 17-290 mumoles/min. Cardiac output was unaffected by the purine infusions, indicating that the reduction of MABP was caused by a reduction of the systemic vascular resistance. Elevated ATP and adenosine concentrations were seen in venous plasma (pulmonary artery) during infusion, while only approximately 10% recovered ATP had been degraded to adenosine. On the other hand, in arterial plasma, virtually all nucleotides had been eliminated whereas the adenosine concentrations in plasma ranged between 5 and 20 microM. The magnitude of the vasodilatation was strictly related to the arterial plasma adenosine level irrespective of whether ATP or adenosine was infused. Thus, adenosine probably mediates the vasodilatory effect of ATP.
通过高效液相色谱法（HPLC）对犬体内ATP和腺苷（静脉输注）的血流动力学效应进行了研究，并同时对血浆中的嘌呤进行了定量测定。在两个实验中，在使用腺苷摄取抑制剂双嘧达莫治疗期间进行了输注。在17 - 290微摩尔/分钟的输注速率下，ATP和腺苷均可使平均动脉血压（MABP）降低50 - 60%。心脏输出量不受嘌呤输注的影响，这表明MABP的降低是由全身血管阻力的降低所致。输注期间，静脉血浆（肺动脉）中ATP和腺苷浓度升高，而仅有约10%回收的ATP降解为腺苷。另一方面，在动脉血浆中，几乎所有核苷酸均已消除，而血浆中腺苷浓度在5至20微摩尔之间。无论输注的是ATP还是腺苷，血管舒张的程度都与动脉血浆腺苷水平密切相关。因此，腺苷可能介导了ATP的血管舒张作用。
